免疫原
Synthesized peptide derived from human UACA
特异性
This antibody detects endogenous levels of UACA at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). ; Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).
基因名称（Gene Name）
UACA KIAA1561
蛋白名称
Uveal autoantigen with coiled-coil domains and ankyrin repeats
其他名称
NUCLING;UACA;UACA KIAA1561;Uveal autoantigen with coiled-coil domains and ankyrin repeats
细胞定位
Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Expressed diffusely in cytoplasm.
组织表达
Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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