免疫原
Synthesized peptide derived from human UBP21 AA range: 50-100
特异性
This antibody detects endogenous levels of UBP21 at Human/Mouse/Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.129% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016],
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.,similarity:Belongs to the peptidase C19 family. USP21 subfamily.,tissue specificity:Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.,
基因名称（Gene Name）
USP21 USP23 PP1490
其他名称
Deubiquitinating enzyme 21;deubiquitinating enzyme 23;EC 3.1.2.15;ESTM28;MGC3394;NEDD8-specific protease;Ubiquitin carboxyl terminal hydrolase 21;ubiquitin carboxyl terminal hydrolase 23;Ubiquitin carboxyl-terminal hydrolase 21;ubiquitin specific peptidase 21;Ubiquitin specific processing protease 21;ubiquitin specific protease 16;ubiquitin specific protease 21;ubiquitin specific protease 23;Ubiquitin thioesterase 21;Ubiquitin thiolesterase 21;ubiquitin thiolesterase 23;ubiquitin-specific protease 23;formerly;Ubiquitin-specific-processing protease 21;UBP21_HUMAN;USP16;Usp21;USP23;W53272;UBP21;USP21 USP23 PP1490;Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)
细胞定位
Cytoplasm . Nucleus .
组织表达
Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
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