免疫原
The specific immunogen used to produce this antibody is proprietary information.
组成（Formulation）
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
稀释比例
IHC 1:200-1:1000; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
纯化工艺（Immunogen）
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
背景（Background）
The calpains , calcium-activated neutral proteases , are nonlysosomal , intracellular cysteine proteases. The mammalian calpains include ubiquitous , stomach-specific , and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large , catalytic subunits associated with a common small , regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme , calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq , Nov 2010] ,
功能
Catalytic activity:Broad endopeptidase specificity. ,cofactor:Binds 3 calcium ions. ,enzyme regulation:Activated by micromolar concentrations of calcium and inhibited by calpastatin. ,Function:Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. ,online information:Calpain ,similarity:Belongs to the peptidase C2 family. ,similarity:Contains 1 calpain catalytic domain. ,similarity:Contains 4 EF-hand domains. ,subcellular location:Translocates to the plasma membrane upon Ca (2+) binding. ,subunit:Forms a heterodimer with a small (regulatory) subunit (CAPNS1) . ,tissue specificity:Ubiquitous. ,
基因名称（Gene Name）
CAPN1 CANPL1 PIG30
蛋白名称
Calpain-1 catalytic subunit (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
其他名称
CAPN1 CANPL1 PIG30;Calpain-1 catalytic subunit (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
细胞定位
Cytoplasm . Cell membrane . Translocates to the plasma membrane upon Ca (2+) binding. In granular keratinocytes and in lower corneocytes , colocalizes with FLG and FLG2 (PubMed:21531719) . .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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