免疫原
Synthesized peptide derived from human PAN2
特异性
This antibody detects endogenous levels of PAN2 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
基因名称（Gene Name）
PAN2 KIAA0710 USP52
蛋白名称
PAB-dependent poly(A)-specific ribonuclease subunit 2 (hPan2) (Inactive ubiquitin carboxyl-terminal hydrolase 52)
其他名称
PAN2 KIAA0710 USP52;PAB-dependent poly(A)-specific ribonuclease subunit 2 (hPan2) (Inactive ubiquitin carboxyl-terminal hydrolase 52)
细胞定位
Cytoplasm . Cytoplasm, P-body . Nucleus . Shuttles between nucleus and cytoplasm. .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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