免疫原
Synthesized peptide derived from human RASGRF2
特异性
This antibody detects endogenous levels of RASGRF2 at Human, Mouse,Rat
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
基因名称(Gene Name)
RASGRF2 GRF2
蛋白名称
Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2)
其他名称
GRF2;Ras guanine nucleotide exchange factor 2;Ras protein specific guanine nucleotide releasing factor 2;Ras-GRF2;Ras-specific guanine nucleotide-releasing factor 2;RASGRF2;RGRF2_HUMAN;RASGRF2 GRF2;Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2)
细胞定位
Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). .
组织表达
Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)