WB

Synthesized peptide derived from human CTC1. AA range:663-733

This antibody detects endogenous levels of CTC1 at Human, Mouse

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

WB 1:500-2000

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner , while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation . However , the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha . The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins . Involved in telomere maintenance . Involved in genome stability . May be in involved in telomeric C-strand fill-in during late S/G2 phase (By similarity) .

CTC1 C17orf68

CST complex subunit CTC1 (Conserved telomere maintenance component 1) (HBV DNAPTP1-transactivated protein B)

=_xlfn.TEXTJOIN(";",TRUE,W3134,X3134,Y3134,Z3134)

80169

Q2NKJ3

68964

Q5SUQ9

Nucleus . Chromosome , telomere . A transmembrane region is predicted by sequence analysis tools (ESKW , MEMSAT and Phobius) ; however , given the telomeric localization of the protein , the relevance of the transmembrane region is unsure in vivo. .

-15°C to -25°C/1 year(Do not lower than -25°C)