免疫原
Synthesized peptide derived from human TRPC4AP
特异性
This antibody detects endogenous levels of TRPC4AP at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control . The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway . The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation . Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity). Involved in JNK activation via its interaction with TRAF2 (By similarity). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response
基因名称（Gene Name）
TRPC4AP C20orf188 TRRP4AP
蛋白名称
Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS)
其他名称
C2orf188;TRPC4AP;Chromosome 2 open reading frame 188;Protein TAP1;Protein TRUSS;Short transient receptor potential channel 4 associated protein;Short transient receptor potential channel 4-associated protein;TAP1 protein;TNF receptor ubiquitous scaffolding/signaling protein;TNF-receptor ubiquitous scaffolding/signaling protein;TP4AP_HUMAN;Transient receptor potential cation channel;subfamily C;member 4 associated protein;Trp4 associated protein;Trp4-associated protein;Trpc4 associated protein;Trpc4-associated protein;TRRP4AP;TRUSS;Tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein;TRPC4AP C20orf188 TRRP4AP;Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS)
细胞定位
Cytoplasm, perinuclear region .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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