免疫原
The antiserum was produced against synthesized peptide derived from human Ephrin B1/B2/B3 around the phosphorylation site of Tyr324. AA range:290-339
特异性
Phospho-Ephrin-B1/2/3 (Y324) Polyclonal Antibody detects endogenous levels of Ephrin-B1/2/3 protein only when phosphorylated at Y324.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008],
功能
disease:Defects in EFNB1 are a cause of craniofrontonasal syndrome (CFNS) [MIM:304110]; also known as craniofrontonasal dysplasia (CFND). CFNS is an X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies.,function:Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.,induction:By TNF-alpha.,PTM:Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.,similarity:Belongs to the ephrin family.,subunit:Interacts with GRIP1 and GRIP2.,tissue specificity:Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas.,
基因名称（Gene Name）
EFNB1/EFNB2/EFNB3
其他名称
EFN B2;EFNB 2;Efnb2;EFNB2_HUMAN;Eph related receptor tyrosine kinase ligand 5;EPH-related receptor tyrosine kinase ligand 5;ephrin B2;Ephrin-B2;EphrinB2;EPLG 5;EPLG5;Htk L;HTK ligand;HTK-L;HTKL;LERK 5;LERK-5;LERK5;Ligand of eph related kinase 5;MGC126226;MGC126227;MGC126228;OTTMUSP24973;CFND;CFNS;Craniofrontonasal syndrome (craniofrontonasal dysplasia);EFL 3;EFL-3;EFL3;EFNB1;EFNB1_HUMAN;Elk L;ELK ligand;ELK-L;Eph related receptor tyrosine kinase ligand 2;EPH-related receptor tyrosine kinase ligand 2;Ephrin-B1;EPLG2;LERK 2;LERK-2;LERK2;Ligand of eph related kinase 2;MGC8782;EFL 6;EFL6;EFNB 3;Efnb3;EFNB3_HUMAN;EPH related receptor transmembrane ligand ELK L3;EPH related receptor transmembrane ligand ELKL3;EPH related receptor tyrosine kinase ligand 8;EPH-related receptor transmembrane ligand ELK-L3;EPH-related receptor tyrosine kinase ligand 8;Ephrin B3;Ephrin-B3;EphrinB3;EPLG 8;EPLG8;LERK 8;LERK-8;LERK8;Ephrin-B1/2/3;EFNB1/EFNB2/EFNB3;EP
人蛋白质序列数据库
P98172/P52799/Q15768
细胞定位
Cell membrane ; Single-pass type I membrane protein . Membrane raft . May recruit GRIP1 and GRIP2 to membrane raft domains. .; [Ephrin-B1 C-terminal fragment]: Cell membrane ; Single-pass type I membrane protein .; [Ephrin-B1 intracellular domain]: Nucleus . Colocalizes with ZHX2 in the nucleus. .
组织表达
Widely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638).
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