免疫原
Synthesized peptide derived from human HELLS
特异性
This antibody detects endogenous levels of HELLS at Human, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis (By similarity).
基因名称(Gene Name)
HELLS PASG SMARCA6 Nbla10143
蛋白名称
Lymphoid-specific helicase (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
其他名称
EC:3.6.4.-;helicase;lymphoid;LSH;Lymphoid specific helicase;Lymphoid-specific helicase;HELLS PASG SMARCA6 Nbla10143;Lymphoid-specific helicase (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
细胞定位
Nucleus . Closely associated with pericentric heterochromatin. .
组织表达
Highly expressed in proliferative tissues such as adult thymus and testis, and expressed at lower levels in uterus, small intestine, colon, and peripheral blood mononuclear cells. Also expressed in neoplastic cell lines including those derived from myeloid and lymphoid leukemias.
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)