免疫原
Synthesized peptide derived from human C19orf21
特异性
This antibody detects endogenous levels of C19orf21 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.
蛋白名称
Uncharacterized protein C19orf21
其他名称
MISP;Mitotic interactor and substrate of PLK1;Mitotic spindle positioning protein;C19orf21;Uncharacterized protein C19orf21
细胞定位
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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