免疫原
Recombinant protein corresponding to fragment (aa/225-430) GOT2 .
特异性
This antibody detects endogenous levels of GOT2.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013],
功能
catalytic activity:L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.,cofactor:Pyridoxal phosphate.,function:Facilitates cellular uptake of long-chain free fatty acids.,miscellaneous:In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,
其他名称
KAT4;DEE82;KATIV;KYAT4;mitAAT;GOT2;AATM_HUMAN;AL022787;Aspartate aminotransferase;Aspartate aminotransferase 2;mitochondrial;ASPATA;EC 2.6.1.1;FABP 1;FABP pm;FABP-1;FABPpm;Fatty acid binding protein;Fatty acid-binding protein;FLJ40994;Glutamate oxaloacetate transaminase 2;Glutamate oxaloacetate transaminase;Glutamic oxaloacetic transaminase 2;mitochondrial (aspartate aminotransferase 2);Got 2;Kynurenine aminotransferase IV;mAspAT;MGC102129;MGC115763;Mitochondrial aspartate aminotransferase;OTTMUSP00000017748;Plasma membrane fatty acid binding protein;Plasma membrane-associated fatty acid-binding protein;Transaminase A.
Fields
>>Arginine biosynthesis;>>Alanine, aspartate and glutamate metabolism;>>Cysteine and methionine metabolism;>>Arginine and proline metabolism;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>Phenylalanine, tyrosine and tryptophan biosynthesis;>>Metabolic pathways;>>Carbon metabolism;>>2-Oxocarboxylic acid metabolism;>>Biosynthesis of amino acids;>>Fat digestion and absorption
细胞定位
Mitochondrion matrix . Cell membrane . Exposure to alcohol promotes translocation to the cell membrane. .
组织表达
Epithelium,Gastric mucosa,Muscle,
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