免疫原
Synthesized peptide derived from human INO80
特异性
This antibody detects endogenous levels of INO80 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair . Binds DNA . As part of the INO80 complex, remodels chromatin by shifting nucleosomes . Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator . Involved in UV-damage excision DNA repair . The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation . Involved in DNA replication . Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle .
基因名称（Gene Name）
INO80 INO80A INOC1 KIAA1259
蛋白名称
DNA helicase INO80 (hINO80) (EC 3.6.4.12) (INO80 complex subunit A) (Putative DNA helicase INO80 complex homolog 1)
其他名称
Chromatin-remodeling ATPase INO80;DNA helicase-related INO80 complex homolog 1;DNA helicase-related protein INO80;EC:3.6.4.-;hINO80;INO80;INO80 INO80A INOC1 KIAA1259;DNA helicase INO80 (hINO80) (EC 3.6.4.12) (INO80 complex subunit A) (Putative DNA helicase INO80 complex homolog 1)
细胞定位
Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Chromosome . Localizes to the cytoplasm in quiescent cell (PubMed:20237820). Associates with spindle microtubules during mitosis (PubMed:20237820). Colocalizes with PCNA at replication forks during S-phase (PubMed:20237820). Recruited to DNA damage sites in a ACTR8-dependent manner (PubMed:20971067). .
组织表达
According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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