免疫原
Synthesized peptide derived from part region of human protein
特异性
GBLP Polyclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
domain:The WD repeats domain 5 mediates interaction with TRIM63.,function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.,similarity:Belongs to the WD repeat G protein beta family.,similarity:Contains 7 WD repeats.,subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells.,subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.,
功能
domain:The WD repeats domain 5 mediates interaction with TRIM63.,function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.,similarity:Belongs to the WD repeat G protein beta family.,similarity:Contains 7 WD repeats.,subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells.,subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.,
基因名称（Gene Name）
GNB2L1 HLC7 PIG21
蛋白名称
Guanine nucleotide-binding protein subunit beta-2-like 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7
其他名称
C12-3;GNB2L1;c12.3;Gnb2-rs1;H12.3;HLC-7;PIG21;GB-like;p205;RACK1_CHICK;RACK1;Guanine nucleotide-binding protein subunit beta-like protein 12.3;Receptor for activated C kinase;Receptor of activated protein C kinase 1;Receptor of activated protein kinase C 1 (RACK1);RACK1_BOVIN;Guanine nucleotide-binding protein subunit beta-2-like 1;Receptor of activated protein kinase C 1;GBLP_MACFA;RACK1_HUMAN;Cell proliferation-inducing gene 21 protein;Human lung cancer oncogene 7 protein (HLC-7);RACK1_MOUSE;12-3;RACK1_PIG;RACK1_RAT;GBLP;GNB2L1 HLC7 PIG21;Guanine nucleotide-binding protein subunit beta-2-like 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7
细胞定位
Cell membrane ; Peripheral membrane protein. Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Perikaryon . Cell projection, dendrite . Cell projection, phagocytic cup . Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene-transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310). .
组织表达
In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue.
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