免疫原
Synthesized peptide derived from human S61A1 AA range: 333-383
特异性
This antibody detects endogenous levels of S61A1 at Human/Mouse/Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008],
功能
function:Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.,similarity:Belongs to the secY/SEC61-alpha family.,subunit:Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.,
基因名称（Gene Name）
SEC61A1 SEC61A
其他名称
chunp6898;fb62c11;HSEC61;protein transport protein SEC61 alpha subunit;protein transport protein Sec61 subunit alpha;Protein transport protein Sec61 subunit alpha isoform 1;S61A1_HUMAN;SEC 61;SEC 61A;Sec61 alpha 1;Sec61 alpha 1 subunit;Sec61 alpha 1 subunit (S. cerevisiae);Sec61 alpha-1;SEC61;Sec61 homolog;SEC61A1;sec61aa;S61A1;SEC61A1 SEC61A
Fields
>>Protein export;>>Protein processing in endoplasmic reticulum;>>Phagosome;>>Vibrio cholerae infection
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Localizes exclusively in granular structures in the endoplasmic reticulum (ER). .
组织表达
Expressed in proximal and distal tubules in kidney (at protein level).
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