免疫原
Synthesized peptide derived from the C-terminal region of human EDEM2.
特异性
EDEM2 Polyclonal Antibody detects endogenous levels of EDEM2 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM, Mar 2008],
功能
similarity:Belongs to the glycosyl hydrolase 47 family.,
蛋白名称
ER degradation-enhancing alpha-mannosidase-like 2
其他名称
bA424.1;C2orf31;C2orf49;EDEM 2;EDEM2;EDEM2_HUMAN;ER degradation enhancer mannosidase alpha like 2;ER degradation enhancing alpha mannosidase like 2;ER degradation enhancing alpha mannosidase like protein 2;ER degradation enhancing mannosidase like protein 2;ER degradation-enhancing alpha-mannosidase-like 2;FLJ1783;UNQ573/PRO1135;C20orf31;C20orf49
Fields
>>Protein processing in endoplasmic reticulum
细胞定位
Endoplasmic reticulum lumen .
组织表达
Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
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