免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR2. AA range:1-50
特异性
CD192 Polyclonal Antibody detects endogenous levels of CD192 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009],
功能
function:Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.,online information:CC chemokine receptors entry,polymorphism:Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].,PTM:N-glycosylated.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Binds to HIV-1 Tat.,
蛋白名称
C-C chemokine receptor type 2
其他名称
CC-CKR-2;CCR-2;CCR2A;CCR2B;CD192;CKR2;CKR2A;CKR2B;CMKBR2;MCP-1-R;PCLUD;mJe-r;CCR2_HUMAN;CCR2;C-C CKR-2;Monocyte chemoattractant protein 1 receptor (MCP-1-R);CCR2_MOUSE;JE/FIC receptor;MCP-1 receptor;CCR2_RAT;C-C motif chemokine receptor 2;chemokine (C-C motif) receptor 2;C-C chemokine receptor type 2;Monocyte chemoattractant protein 1 receptor
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway
细胞定位
Cell membrane ; Multi-pass membrane protein . The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. .
组织表达
Expressed by monocytes and IL2-activated NK cells.
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