免疫原
Synthesized peptide derived from human HO-1
特异性
This antibody detects endogenous levels of HO-1 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.39% sodium azide.
稀释比例
IF 1:50-200 IHC-p1:50-200 ,WB 1:1000-2000
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
heme oxygenase 1(HMOX1) Homo sapiens Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.,function:Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.,induction:Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA.,similarity:Belongs to the heme oxygenase family.,
基因名称（Gene Name）
HMOX1 HO HO1
其他名称
Heme oxygenase 1 (HO-1) (EC 1.14.99.3)
Fields
>>Porphyrin metabolism;>>Metabolic pathways;>>HIF-1 signaling pathway;>>Ferroptosis;>>Mineral absorption;>>Pathways in cancer;>>MicroRNAs in cancer;>>Chemical carcinogenesis - reactive oxygen species;>>Hepatocellular carcinoma;>>Fluid shear stress and atherosclerosis
细胞定位
Endoplasmic reticulum membrane ; Single-pass type IV membrane protein ; Cytoplasmic side .
组织表达
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
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