免疫原
Purified recombinant fragment of human WDR5 expressed in E. Coli.
特异性
WDR5 Monoclonal Antibody detects endogenous levels of WDR5 protein.
组成（Formulation）
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
Affinity purification
背景（Background）
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],
功能
function:Accelerates osteoblast differentiation.,similarity:Belongs to the WD repeat WDR5/wds family.,similarity:Contains 7 WD repeats.,subunit:Interacts with HCFC1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Component of a multiprotein complex of 900 kDa containing WDR5.,
蛋白名称
WD repeat-containing protein 5
其他名称
WDR5; BIG3; WD repeat-containing protein 5; BMP2-induced 3-kb gene protein
Fields
>>Cushing syndrome
组织表达
Epithelium,Lung,Spleen,Uterus,
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