免疫原
Synthesized peptide derived from human APOBEC3B
特异性
This antibody detects endogenous levels of APOBEC3B at Human
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
he antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
功能
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepati
蛋白名称
Probable DNA dC->dU-editing enzyme APOBEC-3B (EC 3.5.4.-) (Phorbolin-1-related protein) (Phorbolin-2/3)
组织表达
Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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