背景（Background）
This gene is a member of a group of genes whose transcript levels are increased following
stressful growth arrest conditions and treatment with DNA-damaging agents. The protein
encoded by this gene responds to environmental stresses by mediating activation of the
p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this
gene is mediated by both p53 dependent and independent mechanisms.
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