免疫原
Synthesized peptide derived from human HKDC1
特异性
This antibody detects endogenous levels of HKDC1 at Human, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases . Has low glucose phosphorylating activity compared to other hexokinases . Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity).
蛋白名称
Putative hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1)
细胞定位
Mitochondrion membrane ; Peripheral membrane protein . The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion. .
组织表达
Widely expressed (PubMed:27459389, PubMed:29401404). Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein level) (PubMed:29401404). Present at moderate level in the thyroid follicular epithelium (at protein level) (PubMed:29401404).
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)