免疫原
Synthesized peptide derived from human CREST
特异性
This antibody detects endogenous levels of CREST at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves
基因名称（Gene Name）
SS18L1 CREST KIAA0693
蛋白名称
Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)
细胞定位
Nucleus . Chromosome, centromere, kinetochore . Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). .
组织表达
Ubiquitous; with lowest levels in spleen.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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