免疫原
Synthesized peptide derived from NVL . at AA range: 320-400
特异性
NVL Monoclonal Antibody detects endogenous levels of NVL protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011],
功能
PTM:Phosphorylated.,similarity:Belongs to the AAA ATPase family.,tissue specificity:Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.,
蛋白名称
Nuclear valosin-containing protein-like
其他名称
NVL; Nuclear valosin-containing protein-like; NVLp; Nuclear VCP-like protein
Fields
>>Ribosome biogenesis in eukaryotes
细胞定位
[Isoform 2]: Nucleus, nucleoplasm .; [Isoform 1]: Nucleus, nucleolus . Nucleus, nucleoplasm . Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus. .
组织表达
Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
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