免疫原
The antiserum was produced against synthesized peptide derived from human FSHR. AA range:211-260
特异性
FSHR Monoclonal Antibody detects endogenous levels of FSHR protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
功能
disease:Defects in FSHR are a cause of ovarian dysgenesis 1 (ODG1) [MIM:233300]; also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).,disease:Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS) [MIM:608115]. OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargeme
蛋白名称
Follicle-stimulating hormone receptor
其他名称
FSHR; LGR1; Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Ovarian steroidogenesis
细胞定位
Cell membrane ; Multi-pass membrane protein .
组织表达
Sertoli cells and ovarian granulosa cells.
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