免疫原
Synthesized peptide derived from human MSH5 AA range: 13-63
特异性
This antibody detects endogenous levels of MSH5 at Human/Mouse/Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011],
功能
function:Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis.,similarity:Belongs to the DNA mismatch repair mutS family.,subunit:Heterooligomer of MSH4 and MSH5. Interacts with HJURP.,tissue specificity:Ubiquitous, but highly expressed in testis, and thymus.,
细胞定位
synaptonemal complex,mismatch repair complex,
组织表达
Widely expressed, with high levels in testis and ovary, including granulosa cells (PubMed:9740671, PubMed:28175301). Also expressed in fetal ovary and adrenal gland (PubMed:28175301).
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