免疫原
Synthesized peptide derived from human protein . at AA range: 330-410
特异性
CNDP1 Monoclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.,cofactor:Binds 2 zinc ions per subunit.,disease:Deficiency of CNDP1 may be the cause of homocarnosinosis.,disease:Diabetic patients with the CNDP1 Mannheim allele are less susceptible for nephropathy.,enzyme regulation:Inhibited by the metal chelator 1,10-o-phenantrolin. The inhibitory concentration 50% (IC(50)) is 5 uM.,polymorphism:The number of trinucleotide (CTG) repeat varies among different alleles leading to insertion of Leu residues in the signal peptide. The allele with 5 leucines (as shown in the reference entry) is known as the Mannheim allele.,similarity:Belongs to the peptidase M20A family.,subunit:Homodimer.,tissue specificity:Expressed in adult nervous central system.,
基因名称（Gene Name）
CNDP1 CN1 CPGL2 UNQ1915/PRO4380
蛋白名称
Beta-Ala-His dipeptidase (EC 3.4.13.20) (CNDP dipeptidase 1) (Carnosine dipeptidase 1) (Glutamate carboxypeptidase-like protein 2) (Serum carnosinase)
Fields
>>Arginine and proline metabolism;>>Histidine metabolism;>>beta-Alanine metabolism;>>Metabolic pathways
组织表达
Found in serum and adult nervous central system. Absent in serum from patients with homocarnosinosis.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
