免疫原
Synthesized peptide derived from part region of human protein
特异性
SETB2 Monoclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
SET domain bifurcated 2(SETDB2) Homo sapiens This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
功能
catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,function:Probable histone methyltransferase.,similarity:Belongs to the histone-lysine methyltransferase family.,similarity:Contains 1 MBD (methyl-CpG-binding) domain.,similarity:Contains 1 pre-SET domain.,similarity:Contains 1 SET domain.,tissue specificity:Ubiquitous. Highest expression in heart, testis and ovary.,
基因名称（Gene Name）
SETDB2 C13orf4 CLLD8 KMT1F
蛋白名称
Histone-lysine N-methyltransferase SETDB2 (EC 2.1.1.43) (Chronic lymphocytic leukemia deletion region gene 8 protein) (Lysine N-methyltransferase 1F) (SET domain bifurcated 2)
Fields
>>Lysine degradation;>>Metabolic pathways
细胞定位
Nucleus . Chromosome .
组织表达
Ubiquitous. Highest expression in heart, testis and ovary.
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