免疫原
Synthesized peptide derived from human protein . at AA range: 250-330
特异性
PDE3A Monoclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],
功能
catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Inhibited by cGMP.,function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,online information:PDE3 entry,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,
蛋白名称
cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)
Fields
>>Purine metabolism;>>Metabolic pathways;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Renin secretion;>>Morphine addiction
细胞定位
Membrane ; Multi-pass membrane protein . Cytoplasm, cytosol .
组织表达
Blood,Epithelium,Liver,Myocardium,Penis,Platelet,
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