免疫原
Synthesized peptide derived from Nup88 . at AA range: 330-410
特异性
Nup88 Monoclonal Antibody detects endogenous levels of Nup88 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
功能
function:Essential component of nuclear pore complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Interacts with NUP214/CAN.,tissue specificity:Ubiquitous.,
蛋白名称
Nuclear pore complex protein Nup88
其他名称
NUP88; Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88
Fields
>>Nucleocytoplasmic transport;>>Amyotrophic lateral sclerosis
细胞定位
Nucleus, nuclear pore complex .
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