免疫原
Synthesized peptide derived from human NAPE-PLD. AA range:141-211
特异性
This antibody detects endogenous levels of NAPE-PLD at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid . Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs , primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity) . May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival , partly through RAC1 activation (By similarity) . As a regulator of lipid metabolism in the adipose tissue , mediates the crosstalk between adipocytes , gut microbiota and immune cells to control body temperature and weight. In particular , regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity) .
基因名称（Gene Name）
NAPEPLD C7orf18
蛋白名称
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (N-acyl phosphatidylethanolamine phospholipase D) (NAPE-PLD) (NAPE-hydrolyzing phospholipase D) (EC 3.1.4.54)
其他名称
=_xlfn.TEXTJOIN(";",TRUE,W3208,X3208,Y3208,Z3208)
细胞定位
Golgi apparatus membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein . Nucleus envelope . Nucleus , nucleoplasm . Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids. .
组织表达
Widely expressed. Highest expression in brain , kidney and testis (at protein level) . Expressed in adipose tissue (at protein level) .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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