WB、IHC、IF、ELISA

Synthesized peptide derived from human SOX9 AA range: 1-100

The antibody can specifically recognize human SOX9 protein. In western blotting of SW480 and HepG2 cell lysates, the antibody can label a 60 kDa band corresponding to SOX9.

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)

Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.

1 mg/ml

Sox9 is a transcription factor that plays a key role in chondrocyte differentiation and bone development. It is expressed in cartilage , neural crest , kidney and pancreas.

Disease:Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare , often lethal , dominantly inherited , congenital osteochondrodysplasia , associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones , unusually small scapulae , deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate , micrognatia , flat face and hypertelorism are common. Various defects of the ear are often evident , affecting the cochlea , malleus incus , stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage. ,Function:Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. ,similarity:Contains 1 HMG box DNA-binding domain. ,

SOX9

Transcription factor SOX-9

campomelic dysplasia autosomal sex reversal ; CMD 1 ; CMD1 ; CMPD 1 ; CMPD1 ; SOX 9 ; Sox9 ; SOX9_HUMAN ; SRA 1 ; SRA1 ; SRXX2 ; SRXY10 ; SRY ; sex determining region Y ; box 9 ; campomelic dysplasia autosomal ; SRY ; sex determining region Y ; box 9 ; SRY ; sex determining region Y ; -box 9 ; SRY ; sex-determining region Y ; -box 9 protein ; SRY related HMG box gene 9 ; Transcription factor SOX 9 ; Transcription factor SOX-9 ; transcription factor SOX9

=_xlfn.TEXTJOIN(";",TRUE,W3195,X3195,Y3195,Z3195)

6662

P48436

20682

Q04887

Nuclear

Eye ,PNS ,Testis ,

-15°C to -25°C/1 year(Do not lower than -25°C)