免疫原
Synthesized peptide derived from human TRA2B. AA range:112-182
特异性
This antibody detects endogenous levels of TRA2B at Human, Mouse,Rat
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators , like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.
基因名称(Gene Name)
TRA2B SFRS10
蛋白名称
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
其他名称
=_xlfn.TEXTJOIN(";",TRUE,W3149,X3149,Y3149,Z3149)
组织表达
Highest expression in heart , skeletal muscle and pancreas. Less abundant in kidney , placenta and brain. Lowest expression in kidney and liver.
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)