免疫原
Synthesized peptide derived from human PDXP. AA range:42-112
特异性
This antibody detects endogenous levels of PDXP at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Functions as a pyridoxal phosphate (PLP) phosphatase , which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP) , with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism . Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF) /cofilin family like CFL1 and DSTN. Thereby , regulates cofilin-dependent actin cytoskeleton reorganization , being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine .
基因名称（Gene Name）
PDXP CIN PLP PLPP
蛋白名称
Pyridoxal phosphate phosphatase (PLP phosphatase) (Chronophin)
其他名称
=_xlfn.TEXTJOIN(";",TRUE,W3131,X3131,Y3131,Z3131)
细胞定位
Cytoplasm , cytosol . Cytoplasm , cytoskeleton . Cell projection , ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody. .
组织表达
Ubiquitously expressed (at protein level) (PubMed:23223568) . Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus , it is weakly expressed in all organs except brain (PubMed:14522954 , PubMed:15580268) .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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