免疫原
Synthesized peptide derived from human Slingshot homolog 1/SSH1. AA range:779-849
特异性
This antibody detects endogenous levels of Slingshot homolog 1/SSH1 at Human, Mouse
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin , which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1 , which may also be dephosphorylated and inactivated by this protein.
基因名称(Gene Name)
SSH1 KIAA1298 SSH1L
蛋白名称
Protein phosphatase Slingshot homolog 1 (SSH-like protein 1) (SSH-1L) (hSSH-1L)
其他名称
=_xlfn.TEXTJOIN(";",TRUE,W3130,X3130,Y3130,Z3130)
细胞定位
Cytoplasm , cytoskeleton. Cell projection , lamellipodium. Cleavage furrow. Midbody. Also recruited to actin rich membrane protrusions such as lamellipodia , which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)