免疫原
Synthesized peptide derived from human FANCI. AA range:678-778
特异性
This antibody detects endogenous levels of FANCI at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) . Participates in S phase and G2 phase checkpoint activation upon DNA damage.
基因名称（Gene Name）
FANCI KIAA1794
蛋白名称
Fanconi anemia group I protein (Protein FACI)
其他名称
FANCI KIAA1794;Fanconi anemia group I protein (Protein FACI)
细胞定位
Nucleus . Cytoplasm . Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres , one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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