免疫原
Synthesized peptide derived from human PITRM1. AA range:675-775
特异性
This antibody detects endogenous levels of PITRM1 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing . Has an ATP-independent activity . Specifically cleaves peptides in the range of 5 to 65 residues . Shows a preference for cleavage after small polar residues and before basic residues , but without any positional preference . Degrades the transit peptides of mitochondrial proteins after their cleavage . Also degrades other unstructured peptides . It is also able to degrade amyloid-beta protein 40 , one of the peptides produced by APP processing , when it accumulates in mitochondrion . It is a highly efficient protease , at least toward amyloid-beta protein 40 . Cleaves that peptide at a specific position and is probably not processive , releasing digested peptides intermediates that can be further cleaved subsequently . It is also able to degrade amyloid-beta protein 42 .
基因名称（Gene Name）
PITRM1 KIAA1104 MP1
蛋白名称
Presequence protease;mitochondrial (hPreP) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)
其他名称
PITRM1 KIAA1104 MP1;Presequence protease;mitochondrial (hPreP) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)
细胞定位
Mitochondrion . Mitochondrion matrix .
组织表达
Widely expressed. Expressed at higher level in muscle and heart compared to brain , pancreas , liver , lung and placenta.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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