免疫原
Synthesized peptide derived from human ALP AA range: 251-301
特异性
This antibody detects endogenous levels of ALP at Human/Mouse/Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000; IHC 1:50-300
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene contains a PDZ domain and a LIM domain , indicating that it may be involved in cytoskeletal assembly. In support of this , the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq , Apr 2012] ,
功能
Disease:Quantitative or qualitative alterations of expression have not been detected in facioscapulohumeral muscular dystrophy (FSHD) . ,Function:May play a role in the organization of actin filament arrays within muscle cells. ,similarity:Contains 1 LIM zinc-binding domain. ,similarity:Contains 1 PDZ (DHR) domain. ,subcellular location:Localizes to myofiber Z-lines. ,subunit:Interacts with ACTN2. ,tissue specificity:Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific. ,
细胞定位
Cytoplasm , myofibril , sarcomere , Z line . Localizes to myofiber Z-lines.
组织表达
Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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