免疫原
Synthesized peptide derived from human SHANK1. AA range:372-472
特异性
This antibody detects endogenous levels of SHANK1 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
蛋白名称
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)
其他名称
SHANK1;SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)
细胞定位
Cytoplasm . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Colocalizes with alpha-latrotoxin receptor 1. .
组织表达
Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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