免疫原
Synthesized peptide derived from human TRIM9. AA range:1-95
特异性
This antibody detects endogenous levels of TRIM9 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
基因名称（Gene Name）
TRIM9 KIAA0282 RNF91
蛋白名称
E3 ubiquitin-protein ligase TRIM9 (RING finger protein 91) (Tripartite motif-containing protein 9)
其他名称
TRIM9 KIAA0282 RNF91;E3 ubiquitin-protein ligase TRIM9 (RING finger protein 91) (Tripartite motif-containing protein 9)
细胞定位
Cytoplasm . Cell projection, dendrite . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Cell junction, synapse . Cytoplasm, cytoskeleton . Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810). .
组织表达
Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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