免疫原
Synthesized peptide derived from human ARHGAP10
特异性
This antibody detects endogenous levels of ARHGAP10 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
基因名称（Gene Name）
ARHGAP10 GRAF2
蛋白名称
Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)
其他名称
ARHGAP10;Graf related protein 2;GRAF2;PS GAP;PSGAP;ARHGAP10 GRAF2;Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)
细胞定位
Cytoplasm . Cytoplasm, perinuclear region . Cell membrane . Association to cell membrane is dependent on PH domain. .
组织表达
High levels of expression in heart and skeletal muscle.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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