免疫原
Synthesized peptide derived from human KCC2/SLC12A5
特异性
This antibody detects endogenous levels of KCC2/SLC12A5 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation .
基因名称（Gene Name）
SLC12A5 KCC2 KIAA1176
蛋白名称
Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter)
其他名称
KCC2;KCC2/SLC12A5;SLC12A5;Electroneutral potassium-chloride cotransporter 2;hKCC2;SLC12A5 KCC2 KIAA1176;Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter)
细胞定位
Membrane; Multi-pass membrane protein.
组织表达
Brain specific. Detected in neuronal cells.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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