免疫原
Synthesized peptide derived from human RNF20
特异性
This antibody detects endogenous levels of RNF20 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation.
基因名称（Gene Name）
RNF20 BRE1A
蛋白名称
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (RING finger protein 20)
其他名称
BRE1;BRE1A;hBRE1;RNF20;RNF20 BRE1A;E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (RING finger protein 20)
组织表达
Expressed in the normal brain and also in malignant gliomas (at protein level).
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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