免疫原
Synthesized peptide derived from human FAM134B
特异性
This antibody detects endogenous levels of FAM134B at Human, Mouse,Rat
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes . Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins . Required for long-term survival of nociceptive and autonomic ganglion neurons .
其他名称
JK1;Reticulophagy receptor 1;Reticulophagy regulator 1;RETREG1;FAM134B;Protein FAM134B
细胞定位
Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达
Overexpressed in esophageal squamous cell carcinoma (PubMed:17487424).
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)