免疫原
Synthesized peptide derived from human FEM1C
特异性
This antibody detects endogenous levels of FEM1C at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms . The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation . The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding . Promotes ubiquitination and degradation of SLBP .
基因名称（Gene Name）
FEM1C KIAA1785
蛋白名称
Protein fem-1 homolog C (FEM1c) (FEM1-gamma)
其他名称
Protein fem-1 homolog C;FEM1-gamma;FEM1A;FEM1 gamma;FEM1;FEM1C KIAA1785;Protein fem-1 homolog C (FEM1c) (FEM1-gamma)
组织表达
Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressed at lower levels in other tissues, including cartilage.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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