免疫原
Synthesized peptide derived from human MPEG1
特异性
This antibody detects endogenous levels of MPEG1 at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores (By similarity). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria . Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity).
蛋白名称
Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1)
其他名称
macrophage expressed 1;Macrophage gene 1 protein;MPEG1;Mpg 1;MPG1;Macrophage-expressed gene 1 protein (Macrophage gene 1 protein) (Mpg-1)
细胞定位
[Isoform 1]: Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Bacterial infection induces translocation of the cytoplasmic vesicles to bacterium-containing phagocytic vesicles and fusing of the vesicles. .; [Isoform 2]: Secreted .
组织表达
Expressed constitutively in a variety of cell types including macrophages, natural killer cells, neutrophils, keratinocytes and monocytes (PubMed:26402460, PubMed:28705375, PubMed:7888681). In skin, expressed in both hematopoietic and non-hematopoietic cells with expression detected in a variety of cell types including keratinocytes, fibroblasts and endothelial cells (PubMed:30609079).
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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