免疫原
Synthesized peptide derived from human PCCA
特异性
This antibody detects endogenous levels of PCCA at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites . Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA . Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate . Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).
蛋白名称
Propionyl-CoA carboxylase alpha chain;mitochondrial (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)
其他名称
PCCA;Propionyl-CoA carboxylase alpha chain;mitochondrial (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)
细胞定位
Mitochondrion matrix .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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