免疫原
Synthesized peptide derived from human protein. AA range:100-150
特异性
This antibody detects endogenous levels of FBXO11 at Human,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
基因名称（Gene Name）
FBXO11 FBX11 VIT1 UG063H01
蛋白名称
F-box only protein 11 (Vitiligo-associated protein 1) (VIT-1)
其他名称
F box only protein 11;F box protein 11;F-box only protein 11;FBX11;FBX11_HUMAN;Fbxo11;PRMT9;Protein arginine N methyltransferase 9;Ubiquitin protein ligase E3 component n recognin 6;UBR6;UG63H1;VIT 1;VIT-1;VIT1;Vitiligo associated protein 1;Vitiligo associated protein VIT 1;Vitiligo-associated protein 1;FBXO11 FBX11 VIT1 UG063H01;F-box only protein 11 (Vitiligo-associated protein 1) (VIT-1)
细胞定位
Nucleus. Chromosome.
组织表达
Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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