免疫原
Synthesized peptide derived from human UBXD1
特异性
This antibody detects endogenous levels of UBXD1 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes . As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation . It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins . Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes .
基因名称（Gene Name）
UBXN6 UBXD1 UBXDC2
蛋白名称
UBX domain-containing protein 6 (UBX domain-containing protein 1)
其他名称
UBX domain-containing protein 1;UBX domain-containing protein 6;UBXDC2;UBXN6;UBXN6 UBXD1 UBXDC2;UBX domain-containing protein 6 (UBX domain-containing protein 1)
细胞定位
Cytoplasm . Cytoplasm, cytosol . Membrane ; Peripheral membrane protein . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Early endosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546). May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622). .
组织表达
Enhanced expression in testis.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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