免疫原
Synthesized peptide derived from human ARAP3
特异性
This antibody detects endogenous levels of ARAP3 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.
基因名称（Gene Name）
ARAP3 CENTD3
蛋白名称
Arf-GAP with Rho-GAP domain;ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3)
其他名称
Ankyrin repeat and plekstrin homology domains containing protein 3;ARAP 3;ARF GAP;ARF-GAP RHO-GAP ankyrin repeat and plekstrin homology domains containing protein 3;CENTD3;FLJ2165;Phosphoinositide binding protein;PtdIns 3 4 5 P3 binding protein;RHO GAP;ARAP3 CENTD3;Arf-GAP with Rho-GAP domain;ANK repeat and PH domain-containing protein 3 (Centaurin-delta-3) (Cnt-d3)
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane ; Peripheral membrane protein . Cell projection, lamellipodium . Cell projection, ruffle . Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. .
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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