免疫原
Synthesized peptide derived from human SPP
特异性
This antibody detects endogenous levels of SPP at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides . May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein . Involved in the intramembrane cleavage of the integral membrane protein PSEN1 . Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner . May play a role in graft rejection (By similarity).
基因名称（Gene Name）
HM13 H13 IMP1 PSL3 SPP MSTP086
蛋白名称
Minor histocompatibility antigen H13 (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase)
其他名称
H13;hIMP1;histocompatibility (minor) 13;HM13;IMP 1;IMP1;IMPAS;IMPAS 1;Intramembrane protease 1;MSTP086;Presenilin like protein 3;PSENL3;PSL3;Signal peptide peptidase;SPP;HM13 H13 IMP1 PSL3 SPP MSTP086;Minor histocompatibility antigen H13 (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase)
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein ; Lumenal side .; [Isoform 4]: Cell membrane ; Multi-pass membrane protein .
组织表达
Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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